Experimental Development of Curcumin Nanoparticles for the Management of Inflammatory Disorders

Abstract

Curcumin, a polyphenolic compound derived from Curcuma longa, possesses potent anti-inflammatory and antioxidant properties but is limited by poor water solubility, low bioavailability, and rapid systemic clearance. Nanoparticle-based delivery systems offer a promising strategy to overcome these limitations by enhancing solubility, stability, and controlled release. In this study, curcumin-loaded nanoparticles were experimentally developed using a polymeric encapsulation technique and characterized for physicochemical properties, drug loading, encapsulation efficiency, morphology, and in vitro release behavior. The formulated nanoparticles exhibited nanoscale particle size with low polydispersity, favorable surface charge, and high encapsulation efficiency. In vitro release studies demonstrated sustained curcumin release under physiological conditions. These findings suggest that curcumin nanoparticles may provide an effective biopharmaceutic approach for the management of inflammatory disorders, potentially improving therapeutic outcomes and patient compliance.